Cognitive and behavioral impact of the ketogenic diet in children and adolescents with refractory epilepsy: A randomized controlled trial

Dominique M IJff; Debby Postulart; Danielle A J E Lambrechts; Marian H J M Majoie; Reina J A de Kinderen; Jos G M Hendriksen; Silvia M A A Evers; Albert P Aldenkamp

doi:10.1016/j.yebeh.2016.04.033

Cognitive and behavioral impact of the ketogenic diet in children and adolescents with refractory epilepsy: A randomized controlled trial

Dominique M IJff
, Debby Postulart
, Danielle A J E Lambrechts
, Marian H J M Majoie
, Reina J A de Kinderen
, Jos G M Hendriksen
, Silvia M A A Evers
, Albert P Aldenkamp

Maastricht University
Kempenhaeghe Epilepsiecentrum
Maastricht Universitair Medisch Centrum Plus
Trimbos Institute, Netherlands Institute of Mental Health and Addiction
Universiteit Gent
Technische Universiteit Eindhoven

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › Wetenschappelijk › peer review

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Purpose
The ketogenic diet (KD) is increasingly used for the treatment of refractory epilepsy in childhood because of the beneficial effect on seizure reduction. The aim of the current study was to objectively assess cognition and aspects of behavior during the first 4months of a randomized controlled study in children and adolescents.
Methods
Participants from a tertiary epilepsy center were randomized to a KD group (intervention) or a care-as-usual (CAU) group (control). Follow-up assessments on cognition and behavior were performed approximately 4months after initiation of the KD with a combination of parent report questionnaires and individually administered psychological tests for the children.
Results
A total of 50 patients were enrolled in this study, 28 patients from the KD group and 22 patients from the CAU group. The KD group showed lower levels of anxious and mood-disturbed behavior and was rated as more productive. Cognitive test results showed an improvement of activation in the KD group.
Conclusions
This study showed a positive impact of the KD on behavioral and cognitive functioning in children and adolescents with refractory epilepsy. More specifically, an activated mood and cognitive activation were observed in patients treated with the KD.

Originele taal	Engels
Pagina's (van-tot)	153-157
Aantal pagina's	5
Tijdschrift	Epilepsy and Behavior
Volume	60
DOI's	https://doi.org/10.1016/j.yebeh.2016.04.033
Status	Gepubliceerd - jul 2016
Extern gepubliceerd	Ja

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10.1016/j.yebeh.2016.04.033

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IJff, D. M., Postulart, D., Lambrechts, D. A. J. E., Majoie, M. H. J. M., de Kinderen, R. J. A., Hendriksen, J. G. M., Evers, S. M. A. A., & Aldenkamp, A. P. (2016). Cognitive and behavioral impact of the ketogenic diet in children and adolescents with refractory epilepsy: A randomized controlled trial. Epilepsy and Behavior, 60, 153-157. https://doi.org/10.1016/j.yebeh.2016.04.033

@article{5344f9c2921243919968df6a587c979e,

title = "Cognitive and behavioral impact of the ketogenic diet in children and adolescents with refractory epilepsy: A randomized controlled trial",

abstract = "PURPOSE: The ketogenic diet (KD) is increasingly used for the treatment of refractory epilepsy in childhood because of the beneficial effect on seizure reduction. The aim of the current study was to objectively assess cognition and aspects of behavior during the first 4months of a randomized controlled study in children and adolescents.METHODS: Participants from a tertiary epilepsy center were randomized to a KD group (intervention) or a care-as-usual (CAU) group (control). Follow-up assessments on cognition and behavior were performed approximately 4months after initiation of the KD with a combination of parent report questionnaires and individually administered psychological tests for the children.RESULTS: A total of 50 patients were enrolled in this study, 28 patients from the KD group and 22 patients from the CAU group. The KD group showed lower levels of anxious and mood-disturbed behavior and was rated as more productive. Cognitive test results showed an improvement of activation in the KD group.CONCLUSIONS: This study showed a positive impact of the KD on behavioral and cognitive functioning in children and adolescents with refractory epilepsy. More specifically, an activated mood and cognitive activation were observed in patients treated with the KD.",

keywords = "Adolescent, Adolescent Behavior/psychology, Affect, Child, Child Behavior/psychology, Child Behavior Disorders/diagnosis, Child, Preschool, Cognition, Diet, Ketogenic/methods, Drug Resistant Epilepsy/diagnosis, Female, Follow-Up Studies, Humans, Infant, Male, Mood Disorders/diagnosis, Psychological Tests, Surveys and Questionnaires, Treatment Outcome",

author = "IJff, \{Dominique M\} and Debby Postulart and Lambrechts, \{Danielle A J E\} and Majoie, \{Marian H J M\} and \{de Kinderen\}, \{Reina J A\} and Hendriksen, \{Jos G M\} and Evers, \{Silvia M A A\} and Aldenkamp, \{Albert P\}",

year = "2016",

month = jul,

doi = "10.1016/j.yebeh.2016.04.033",

language = "English",

volume = "60",

pages = "153--157",

journal = "Epilepsy and Behavior",

issn = "1525-5050",

publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Cognitive and behavioral impact of the ketogenic diet in children and adolescents with refractory epilepsy

T2 - A randomized controlled trial

AU - IJff, Dominique M

AU - Postulart, Debby

AU - Lambrechts, Danielle A J E

AU - Majoie, Marian H J M

AU - de Kinderen, Reina J A

AU - Hendriksen, Jos G M

AU - Evers, Silvia M A A

AU - Aldenkamp, Albert P

PY - 2016/7

Y1 - 2016/7

N2 - PURPOSE: The ketogenic diet (KD) is increasingly used for the treatment of refractory epilepsy in childhood because of the beneficial effect on seizure reduction. The aim of the current study was to objectively assess cognition and aspects of behavior during the first 4months of a randomized controlled study in children and adolescents.METHODS: Participants from a tertiary epilepsy center were randomized to a KD group (intervention) or a care-as-usual (CAU) group (control). Follow-up assessments on cognition and behavior were performed approximately 4months after initiation of the KD with a combination of parent report questionnaires and individually administered psychological tests for the children.RESULTS: A total of 50 patients were enrolled in this study, 28 patients from the KD group and 22 patients from the CAU group. The KD group showed lower levels of anxious and mood-disturbed behavior and was rated as more productive. Cognitive test results showed an improvement of activation in the KD group.CONCLUSIONS: This study showed a positive impact of the KD on behavioral and cognitive functioning in children and adolescents with refractory epilepsy. More specifically, an activated mood and cognitive activation were observed in patients treated with the KD.

AB - PURPOSE: The ketogenic diet (KD) is increasingly used for the treatment of refractory epilepsy in childhood because of the beneficial effect on seizure reduction. The aim of the current study was to objectively assess cognition and aspects of behavior during the first 4months of a randomized controlled study in children and adolescents.METHODS: Participants from a tertiary epilepsy center were randomized to a KD group (intervention) or a care-as-usual (CAU) group (control). Follow-up assessments on cognition and behavior were performed approximately 4months after initiation of the KD with a combination of parent report questionnaires and individually administered psychological tests for the children.RESULTS: A total of 50 patients were enrolled in this study, 28 patients from the KD group and 22 patients from the CAU group. The KD group showed lower levels of anxious and mood-disturbed behavior and was rated as more productive. Cognitive test results showed an improvement of activation in the KD group.CONCLUSIONS: This study showed a positive impact of the KD on behavioral and cognitive functioning in children and adolescents with refractory epilepsy. More specifically, an activated mood and cognitive activation were observed in patients treated with the KD.

KW - Adolescent

KW - Adolescent Behavior/psychology

KW - Affect

KW - Child

KW - Child Behavior/psychology

KW - Child Behavior Disorders/diagnosis

KW - Child, Preschool

KW - Cognition

KW - Diet, Ketogenic/methods

KW - Drug Resistant Epilepsy/diagnosis

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Infant

KW - Male

KW - Mood Disorders/diagnosis

KW - Psychological Tests

KW - Surveys and Questionnaires

KW - Treatment Outcome

U2 - 10.1016/j.yebeh.2016.04.033

DO - 10.1016/j.yebeh.2016.04.033

M3 - Article

C2 - 27206235

SN - 1525-5050

VL - 60

SP - 153

EP - 157

JO - Epilepsy and Behavior

JF - Epilepsy and Behavior

ER -

Cognitive and behavioral impact of the ketogenic diet in children and adolescents with refractory epilepsy: A randomized controlled trial

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